Hand and finger functions gets affected
Walking will get affected. slipping and falling is something to watch out. Please see a doctor who can provide orthopedic support to limbs.
Speech will get affected. Should contact a speech Therapist and find alternative ways of communication.
swallowing will get affected. Since Proper Nutrition is one of the most important factor in the management of ALS, if you find difficult to swallow, please get PEG feeding Tube surgery(direct to the stomach, not through the nose) as soon as possible. sooner is better that later in this case, and managing PEG feeding is not very difficult.
Respiration will get affected. will need BIPAP machine. If Respiration problem is severe, one may need Tracheotomy surgery.

Controlling Depression, Try to have a positive attitude towards life, meditation and positive thinking will help. Nuedexta is helpful with extreme mood swings, depression and excess saliva.